Palliative systemic therapy for women with recurrent epithelial ovarian cancer: current options

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Palliative systemic therapy for women with recurrent epithelial ovarian cancer: current options

OBJECTIVES To review the available systemic treatments for women with recurrent ovarian cancer. METHODS A literature review was conducted for recurrent ovarian cancer articles in English, including randomized trials, Phase II trials, or reviews. RESULTS We discuss the efficacy and toxicity outcomes associated with systemic therapy for platinum-sensitive and platinum-resistant ovarian cancer...

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Palliative surgery for intestinal obstruction due to recurrent ovarian cancer.

BACKGROUND Intestinal Obstruction is a frequent complication after operation for Ovarian Cancer. This study was done to see the outcome of palliative surgery for Intestinal Obstruction due to recurrent ovarian Cancer. METHODS We retrospectively evaluated the records of all the patients who presented with intestinal obstruction after operations for Ovarian Cancer in all the three Surgical Unit...

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Optimal chemotherapy treatment for women with recurrent ovarian cancer

QUESTION What is the optimal chemotherapy treatment for women with recurrent ovarian cancer who have previously received platinum-based chemotherapy? PERSPECTIVES Currently, standard primary therapy for advanced disease involves a combination of maximal cytoreductive surgery and chemotherapy with carboplatin plus paclitaxel or with carboplatin alone. Despite initial high response rates, a lar...

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Treatment of recurrent epithelial ovarian cancer

Epidemiologic analysis reveals that the mortality rate from ovarian cancer is continuously decreasing due to the improvement of surgery and chemotherapy. However, the prognosis of ovarian cancer patients is still unsatisfactory overall considering that only 30% of patients are alive after five years. In fact, although surgery and first-line systemic chemotherapy induces complete and partial res...

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Antivascular Therapy for Epithelial Ovarian Cancer

Ovarian cancer is the fifth largest cancer killer in women. Improved understanding of the molecular pathways implicated in the pathogenesis of ovarian cancer has led to the investigation of novel targeted therapies. Ovarian cancer is characterized by an imbalance between pro- and antiangiogenic factors in favor of angiogenesis activation. Various antivascular strategies are currently under inve...

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ژورنال

عنوان ژورنال: OncoTargets and Therapy

سال: 2013

ISSN: 1178-6930

DOI: 10.2147/ott.s30238